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KMID : 0357920050390050307
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Korean Journal of Pathology
2005 Volume.39 No. 5 p.307 ~ p.312
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Expression of Hypoxia Inducible Factor-1 in Invasive Squamous Cell Carcinoma of Uterine Cervix Treated by Radiotherapy
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Lee Kyung-Ja
Yoo Eun-Sun
Park Soo-Yeun
Park Hye-Sook
Suh Hyun-Suk
Kim Seung-Cheol
Shim Ki-Nam
Jung Sung-Ae
Yoo Kwon
Sung Sun-Hee
Cho Min-Sun
Lee Shi-Nae
Park Hae-Young
Moon Hye-Sung
Lee Kyung-Eun
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Abstract
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Background: Hypoxia-inducible factor-1 (HIF-1 ) is an intrinsic marker of tumor hypoxia, and this is associated with reduced radiosensitivity. Furthermore, HIF-1 can increase a tumor´´s aggressiveness by promoting neoangiogenesis, cell proliferation and survival, and invasion.
Methods: The expression of HIF-1 was was investigated by performing immunohistochemistry on the cervical tissue specimens obtained from 57 patients who had received radiotherapy combined with or without chemotherapy for stages I-III cervical squamous cell carcinoma. The staining results were compared with anemia, the stage, the radiotherapy response and patient survival by univariate and multivariate analysis.
Results: In 57 patients, the expression of HIF-1 was seen in the tissue specimens of 46 patients (81.7%). Among them, 25 (54.3%), 14 (30.4%), and 7 (15.2%) of the patients´´ tissue specimens showed weak, moderate and strong expressions, respectively. Six patients had a partial response after radiotherapy. Twelve patients (21.1%) died of cervical cancer. The increased expression of HIF-1 was significantly associated (p<0.05) with the disease stage and anemia. There were significant positive correlations between the increased expression of HIF-1 and the poor response after radiotherapy and the patients´´ survival.
Conclusions: The present result suggests that the overexpression of HIF-1 in the uterine cervix could be used as a prognostic indicator for the patients treated with radiotherapy.
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KEYWORD
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Cervix Neoplasms, Carcinoma, Squamous cell, Hypoxia Inducible Factor 1, Immunohistochemistry
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